CAS 4136-95-2, Cat. No EN300-316966
Reagent for esterification and macrolactonization
2,4,6-trichlorobenzoyl chloride (TCBCl), commonly referred to as the Yamaguchi reagent, is a versatile tool in organic synthesis, specifically designed for soft esterification and macrolactonization reactions. This light yellow liquid exhibits sensitivity to moisture. Similar to other highly reactive acid chlorides, the reaction procedure with TCBCl is straightforward and intuitive. The Yamaguchi reagent proves to be an excellent choice for challenging substrates encountered in medicinal chemistry and other complex synthetic scenarios. Its utility extends to the total synthesis of natural products that feature a macrolactone motif, as evidenced by its successful application in numerous such syntheses.
Synonyms: 2,4,6-trichlorobenzoyl chloride, TCBCl