Umemoto Reagent I

CAS 131880-16-5, Cat. No EN300-18527578
Reagent for trifluoromethylation

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Umemoto reagent I is an electrophilic trifluoromethylating agent used for transferring the trifluoromethyl group to nucleophiles such as silyl enol ethers and β-ketoesters¹. It is also employed in catalytic strategies including Pd-catalyzed aromatic C-H trifluoromethylation, Cu-catalyzed trifluoromethylation, and photoredox-catalyzed radical trifluoromethylation². The reagent is a white crystalline solid that should be stored in a cool, dry place due to its potentially harmful properties.

Synonyms: S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate; Umemoto’s reagent I; 5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium tetrafluoroborate; 5-(trifluoromethyl)dibenzothiophen-5-ium, tetrafluoroborate