Trifluoroethanol tosylate

CAS 433-06-7, Cat. No EN300-30885
Reagent for trifluoroethylation

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Trifluoroethanol tosylate is a widely used reagent for the efficient etherification of aromatic alcohols with the -CH₂CF₃ group. It is a solid moisture-sensitive white powder with a relatively low melting point¹. The reagent is selective to aromatic alcohols and ignores other functional groups like carbonyl². The etherification process with this reagent is routine and has a good yield. Additionally, trifluoroethanol tosylate is a valuable precursor for essential building blocks used in the difluoroethenylation of arenes through coupling reaction².

Synonyms: 2,2,2-trifluoroethyl 4-methylbenzenesulfonate; 2,2,2-trifluoroethyl tosylate; trifluoroethanol tosylated; 2,2,2-trifluoroethyl 4-methylbenzene-1-sulfonate; trifluoroethanol tosylated; 2,2,2-trifluoroethyl p-toluenesulfonate