CAS 36635-61-7, Cat. No EN300-154751
Reagent for reductive cyanation of ketones and aldehydes and for synthesis of azoles, pyrroles, oxazoles, imidazoles, thiazoles
TosMIC is a unique and versatile reagent that can be utilized for Van Leusen reaction and for heterocyclic formations. It is a colorless stable solid that, unlike many isocyanides, is odorless. Reductive cyanation of ketones and aldehydes with TosMIC is a reliable reaction that as a result has an excellent yield and can be performed even with very hindered substrates. Beyond its role in the Van Leusen reaction, TosMIC plays a crucial role in the formation of heterocyclic compounds. It provides a straightforward approach to synthesizing a wide range of heterocycles, including azoles, pyrroles, oxazoles, imidazoles, and thiazoles.
Synonyms: Tosylmethyl isocyanide; (4-Methylphenylsulfonyl)methyl isocyanide; (p-Tolylsulfonyl)methyl isocyanide; 1-(Isocyanomethanesulfonyl)-4-methylbenzene; 1-Methyl-4-(((isocyano)methyl)sulfonyl)benzene; 4-Toluenesulfonylmethyl isocyanide; 4-Tolylsulfonylmethyl isocyanide; Isocyanomethyl p-tolyl sulfone