Togni reagent

CAS 887144-97-0, Cat. No EN300-195971
Reagent for trifluoromethylation

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Trifluoromethyl-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole (Togni reagent) is used for direct electrophilic trifluoromethylation of various nucleophiles^1,2. It is a white solid, soluble in most organic solvents, with properties similar to the Togni II reagent². The reagent is also capable of selective reaction with thiols to yield corresponding trifluoromethyl thioethers. Togni reagent is less reactive and offers a softer approach. It has unique properties and is mainly used in reactions with β-keto esters or α-nitro carbonyl compounds^1,3. Recently was developed a methodology for trifluoromethylarylation of alkenes with anilines and the Togni reagent, which offers good yields and utilizes no additives, transition metals, photocatalysts, or an excess of reagents². Using this methodology, the Togni II reagent doesn’t react well or give low yields.

Synonyms: trifluoromethyl-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole; 3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (ACI); 1-trifluoromethyl-3,3-dimethyl-1,2-benziodoxole; 3,3-dimethyl-1-trifluoromethyl-1,2-benzoiodoxole; Togni's Reagent