Togni reagent

CAS 887144-97-0, Cat. No EN300-195971
Reagent for electrophilic trifluoromethylation

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This reagent is used for direct electrophilic trifluoromethylation of many nucleophiles^{[1], [2]}. It is a white solid that is soluble in most organic solvents and has similar properties to the Togni II reagent^[2]. As a Togni II reagent, it is capable of selective reaction with thiols to yield corresponding thioethers. However, this reagent is less reactive and offers a softer approach, has unique properties, and is mainly used for reactions with β-keto esters or α-nitro carbonyl compounds^{[1], [3]}. Recently was developed a methodology for trifluoromethylarylation of alkenes with anilines and the title reagent, which offers good yields and utilizes no additives, transition metals, photocatalysts, or an excess of reagents^[2]. While the Togni II reagent doesn’t undergo or give low yields with this methodology.

Synonyms: Trifluoromethyl-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole; 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (ACI); 1-Trifluoromethyl-3,3-dimethyl-1,2-benziodoxole; 3,3-Dimethyl-1-trifluoromethyl-1,2-benzoiodoxole