Methyl trifluoropyruvate

CAS 13089-11-7, Cat. No EN300-42930
Reagent for cyclization and Friedel–Crafts alkylation

EnamineStore

Methyl trifluoropyruvate is a highly electrophilic reagent due to the strong electron-withdrawing trifluoromethyl group adjacent to the keto functionality. It is widely used in Friedel–Crafts alkylation, aldol condensations, cycloadditions, and carbon–nucleophile additions¹. The reagent reacts smoothly with aromatic and heteroaromatic compounds under mild or catalyst-free conditions, often with excellent yields. High reactivity enables reagent usage in asymmetric catalysis, imine formation, fluorinated amino acids and heterocycles synthesis. Methyl trifluoropyruvate is an air-sensitive and thermally stable colorless to yellow liquid that should be stored away from oxidizers.

Synonyms: methyl 3,3,3-trifluoro-2-oxopropanoate; methyl 3,3,3-trifluoropyruvate; trifluoropyruvic acid methyl ester; propanoic acid, 3,3,3-trifluoro-2-oxo-, methyl ester; methyl 2-oxo-3,3,3-trifluoropropanoate; methyltrifluoropyruvate; pyruvic acid, trifluoro-methyl ester