Sulfonyl chlorides/fluorides

Sulfonyl chlorides/fluorides have proved their importance as intermediates in combinatorial chemistry and drug discovery of sulfonamides – biologically active compounds with wide range of action. The most popular building blocks of this class contain either –SO2F or –SO2Cl groups, which differ in stability and chemical reactivity. Enamine offers over 4 000 sulfonyl chlorides/fluorides from stock ranging from small decorating building blocks to intermediates and complex scaffolds for library synthesis. Our collection is the largest in the world being continuously enriched with novel sulfonyl chlorides/fluorides that we design and synthesize in our labs.

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Sulfonyl chlorides/fluorides

 
Aliphatic
Aromatic
Small rings

Item

Original

Aliphatic


EN300-59507

Aromatic


EN300-244943

Small rings


EN300-76495

Item

Fluorinated

Aliphatic


EN300-138820

Aromatic


EN300-259170

Small rings


EN300-216395

Item

Bifunctional

Aliphatic


EN300-14193

Aromatic


EN300-64600

Small rings


EN300-129502

Novel sulfonyl chlorides/fluorides

Every month we synthesize nearly a hundred new sulfonyl chlorides/fluorides that we immediately commercialize in our catalog available for browsing at EnamineStore. It is only with a delay sometimes of a few months that the new and in many cases unique items are published in the established aggregator platforms. If you are looking for original recently synthesized building blocks we encourage you to use our focused selection of 6 months.

Building blocks for parallel synthesis

Sulfonyl chlorides/fluorides have found a wide application in synthesis of compound libraries first of all because of smoothly running sulfonamide bond formation. Using our in-house developed reactivity filters we have selected a range of sulfonyl chlorides/fluorides that can provide clean reactions and high yields of the products. All compounds having side functionalities that interfere under majority of the reaction conditions have been removed from this set. Such set of sulfonyl chlorides/fluorides can be easily shared on your request.

Screening compounds and fragments

Sulfonyl fluorides are used as reactive probes in molecular biology and drug discovery since they can react selectively with residues of serine, threonine, tyrosine, lysine, cysteine and histidine. We offer unique selections of potential sulfonyl fluoride-based covalent inhibitors from Enamine’s screening compound and fragment collection.

Special subsets

Aliphatic sulfonyl chlorides/fluorides

Heteroaromatic sulfonyl chlorides/fluorides

Sulfonyl fluorides

Functionalized sulfonyl chlorides/fluorides

MADE sulfonyl chlorides/fluorides

Having synthesized thousands of sulfonyl chlorides/fluorides and having numerous starting materials in stock we can easily use our skills and documented knowledge to synthesize in short term analogous compounds to what we publish in our catalog. We have gathered our ideas of such new building blocks in a database that can be shared on request.

Services

Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.

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