Building Blocks Catalog

300 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

1B novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

48B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2024

Recent News

  • 11 April 2024   Press Release

    Metrion Biosciences enhances High Throughput Screening services with access ...

    Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.

  • 27 March 2024   Press Release

    Enamine Announces Expansion of Its Library Synthesis Capabilities

    March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.

  • 01 March 2024   News

    Enamine and Genez International Announce Strategic Collaboration to Launch ...

    We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.

γ-Amino Acids

Aliphatic γ-amino acids have served as core backbone elements of many drug structures. Introduction of cyclic elements and substituents enables restriction of the conformational landscape of the otherwise flexible γ-amino acid chains and changes physicochemical properties of the structures. Enamine offers a plethora of rare and unique γ-amino acid structures for modulating conformation, molecular volume, reactivity, and polarity.

Get more details

Case study

We offer

Over 100 γ-amino acids from stock on 5-10 gram scale.

Benzene Perfect Match

The benzene ring is the most common structural fragment in drugs. In 2019, two groups, one from Enamine and another from Merck, independently introduced difluorobicyclo[1.1.1]pentane, a structure that matches the exact molecular volume of benzene. The isosteric replacement of a phenyl ring with difluorobicyclo[1.1.1]pentane maintains the molecular volume while substantially increasing the sp³-character and elevating the solubility of the molecule. Since 2019, our chemists have expanded the panel of difluorobicyclo[1.1.1]pentanes for use in medicinal chemistry.

Get more details

Concept

We offer

Over 50 difluorobicyclo[1.1.1]pentanes from stock on 5-10 gram scale.

Advances in Fluorinated Amino Acids

Fluorine-containing amino acids play a crucial role in modulating molecular polarity, volume, stabilizing specific conformations, and adjusting pKa providing invaluable support in the design of drugs and peptidomimetics. Our team of skilled chemists specializes in synthesizing cutting-edge fluorinated amino acids, with a significant number exclusively offered through Enamine. These novel compounds are frequently incorporated into our inventory even before their publication.

Get more details

Case study


We offer

Over 100 fluorine-containing amino acids from stock on 5-10 gram scale.

3D-Shaped Scaffolds

Cyclic molecular skeletons are widely applied in the construction of medicinal molecules due to their ability to occupy binding pockets and impose conformational restrictions. Among these structures, symmetric forms like cubane and adamantane have been prevalent. In exploring their creative potential, Enamine chemists have prepared a panel of non-classical 3D-shaped cyclic scaffolds capable of occupying intermediate molecular volumes and lipophilicity values.

Get more details

Concept


We offer

Over 50 non-classical 3D-shaped compounds from stock on 5-10 gram scale.

Speed, Quality, and Novelty

Advancements of new technologies and promising discoveries is progressing faster and more intensively with each passing day. Therefore, Enamine, a global leader in the chemical building block market, has developed a special product - the Fast MADE Building Blocks. This is a special set of Enamine MADE (MAke-on-DEmand) building blocks (BBs) that will be synthesized and delivered to our customers in ultra-short terms.

Get more details

 

Such compounds are synthesized within 7‑10 days, through 1-3 commonly utilized procedures (Amidation, heterocyclization, arylation, Grignard reaction, reductive amidation, etc.) with a very high success rate (more than 80%). They are readily available through proven synthetic protocols using our in stock building blocks. It takes just 2‑3 weeks from the moment of the order to deliver to our customers.

Well-validated synthesis protocols and the availability of a large amount of various starting raw materials in stock (above 300,000 BBs in gram quantities and 10,000 BBs in quantities > 1 kg), allow us quickly and easily synthesize more than 90M Fast MADE Building Blocks.

Our highly qualified and experienced specialists are constantly working to ensure that the set of the Fast MADE Building Blocks continues to grow, and synthesis protocols are being improved.

The jointly acquired broad experience now allows us to offer our customers a large number of diverse compounds. Almost all the compounds are novel, and not available through other suppliers. The Fast MADE includes diverse classes of chemical compounds, such as alcohols, primary and secondary amines, amides, sulfonyl chlorides, halides, carboxylic acids, etc.

Key Facts:

  • Your ordered compounds and compound sets will be synthesized and delivered to you within a period of up to 2‑3 weeks;
  • In-stock availability of raw materials directly at Enamine enabling immediate start of the synthesis;
  • Well-developed, standardized, and improved synthesis protocols allow us to obtain targeted Building Blocks with very high success rates (more than 80%) in the shortest possible time;
  • All of our chemical building blocks undergo extensive quality control by NMR and LC-MS, and purity is guaranteed to be over 95%.

You can conveniently make an online substructure or similarity search for novel, previously unseen compounds at our partner website: https://chem-space.com/search, the only online resource that has the comprehensive and most up-to-date collection of Fast MADE Building Blocks.

Fast MADE Building Blocks

Molecular Properties

Categories
Number of items
Secondary Amines
24 220 156
Alcohols
12 692 509
Primary Amines
7 984 663
ArylHalides
7 110 834
Alkenes
3 128 158
CarboxylicAcids
2 758 528
AlkylHalides
2 398 504
Acetylenes
1 660 731
Esters
978 958
Ketones
719 905
Aminoacids
480 301
13bisNucleophiles
95 335
Azides
52 124
Boronics
44 983
SulfonylHalides
8 858
ElementOrganics
6 374
Acylhalides
3 842
13bisElectrophiles
3 501
Aldehydes
107

FOLLOW US