Building Blocks Catalog

284 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

210 Million novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

31B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from October 2022

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Building Block Sets for Library Synthesis

Access to the diverse and highly representative Enamine building block collection provides obvious benefits for SAR exploration and other library synthesis projects. However, they are often outstripped by the costly routine in-house weighing operations and the necessity to develop and maintain an internal building block archive. With Enamine, you can purchase a pre-weighted building block set in exactly the quantity you need for your next reaction and still have full access to our entire stock collection without limitation to your selection. Please download our stock building block database from here.

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The building blocks will be weighted free-of-charge in low-mg- or µmol-amounts in the containers of your choice. These can be 1 Dram or 2 Dram reaction vials with pressure relief caps, any other vials appropriately labeled with our building block ID’s or 2D-barcoded 0.75 or 1.4 mL tubes in racks. You can also provide your own reaction containers. All you need to do, when you receive the reagent set, is to add solvent and carry out a reaction with your starting compound.

Quick Building Block* / Quick Monomer Program. In case of the regular needs for supply of the building sets we offer an optimized set-up enabling minimal delivery times. It is based on the pre-agreed order and logistics workflow and flat building block prices. When all terms are part of our agreement, delivery can take as quickly as 1-3 days.

* The term “Quick Building Blocks” was coined by Christopher J. Helal, et al. ACS Medicinal Chemistry Letters 2019 10 (8), 1104-1109 in their study of a novel business partnership that aims at just-in-time, economical access to a large number of diverse commercial building blocks.

Boron-containing heterocyclic scaffolds with active halogens

The Suzuki–Miyaura cross-coupling of boronic acid derivatives is one of the most used reactions in organic and medicinal chemist's toolbox. The rapid advancement of this method resulted in its efficient application for the late-stage modification of biologically active substrates and construction of combinatorial libraries. Herein, we offer a library of heterocyclic boronic esters with active halogen atoms. They can be used for metal-mediated cross-coupling reactions followed by the stepwise a nucleophilic aromatic substitution (SNAr) to produce functionalized products.

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Case studies

We offer

>100 unique heterocyclic boronic esters on a 5-50 g scale from stock.

MedChem Highlights

Aliphatic Pinacol Boronates for Medicinal Chemistry

Alkyl pinacol boronic esters have been routinely used for the synthesis of complex target molecules due to their low toxicity and stability. They can participate in cross-coupling and other boron-based transformations. It is expected that there may be a demand from the chemical industry for readily diversifiable chiral building blocks for use in construction of new chemical libraries. In this context, Enamine offers a library aliphatic pinacol boronates. We also have designed a library of pinacol boronates that are readily prepared in enantiomerically enriched fashion, and that can participate in cross coupling and other boron-based transformations.

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Case studies

We offer

>100 unique boron-containing building blocks

MADE (Make-on-Demand) Building Blocks. These molecules can be synthesized upon request within 4-6 weeks.

MedChem Highlights

Building Blocks

Building blocks are the essence of our business and our main advantage used to build up all other products and services. Get all the compounds you need directly from the producer in one place, and embody your creativity with our building block collection.

Building Block Sets for Library Synthesis

Pre-weighted building blocks sets in exact amount and reaction vials you need for your next small library synthesis.

Building Blocks Catalog

Enamine owns the world’s largest stock collection of building blocks currently exceeding 284 000 compounds. Access our comprehensive SD Files and supporting documents for you research.

MADE Building Blocks

Discover unexplored unique chemotypes with our MADE collection. MAke-on-DEmand (MADE) building blocks are a 680M catalog of reagents that can be synthesized within several weeks using short pre-validated reaction sequences, our chemical experience, and starting materials from our stock.

Functional Classes

To save your time and efforts, we conveniently categorized the entire Enamine's building blocks collection by chemical functional groups: carboxylic acids, primary and secondary amines, boronic compounds, etc. Download latest selections and special subsets as separate SD files.

DEL-compatible scaffolds

Reagents compatible with DNA-encoded libraries synthesis and related technologies. Choose among bi- and trifunctional compounds with nearly any combination of suitable functional groups.

MedChem Highlights

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Deuterium-Containing Building Blocks for Drug Design

Selective incorporation of deuterium into organic molecules can profoundly alter their physical, chemical and biological properties. Compared to hydrogen, deuterium displays a smaller molar volume (by 0.140 cm3/mol per atom), is less lipophilic (Δ logPoct = - 0.006) and might display a slightly different pKa. More importantly, C-D bonds are shorter (by 0.005 Å) and at times more stable to oxidative processes. This helps protect deuterated compounds from enzymatic degradation in the liver, increasing the compound’s half-life. In this context, Enamine offers a library of deuterium-containing building blocks for drug design.

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Case studies

We offer

deuterium-containing building blocks from stock on a 5-10 g scale.

MedChem Highlights

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