Apart from classical perfluoroalkyl-containing synthones (e.g. Ethyl trifluoroacetate, Trifluoroacetaldehyde, 1,1,1-Trifluoroacetone, 1,1,1-Trifluoroacetylacetone, Ethyl 1,1,1-trifluoroacetoacetate etc.) the arsenal of the reagents includes:
- DAST, MorphDAST and Sulfur tetrafluoride;
- Hydrogen fluoride;
- Metal fluorides and TBAF;
- Tetrafluoroboric acid (for Schiemann process);
- Trifluorotrimethylsilane;
- Trifluoromethyl iodide;
- Trifluoromethyl diazomethane;
- Phenyl(thifluorometyl)mercury;
- Trifluoroacetonitrile;
- Perfluoropropene and its epoxide.
The compounds obtained in such way are original, in many cases unavailable at any other supplier. Many of them were obtained by stereoselective routes; therefore, they are enantiomerically pure or enriched. The procedures employing the reagents mentioned above allow obtaining a large diversity of original fluorine-containing building blocks at 1–10 g scale; novel compounds of the requested structure can be obtained in 4–8 weeks.
Below, we show some examples of the Original Fluorine-Substituted Building Block set.
Carboxylic acids
Reactive aryl halogenides
Trifluoromethyl ketones
Trifluoromethyl β-dicarbonyl compounds
Cyclic amides
Aliphatic amines
Aromatic amines
