The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold

A facile method for the synthesis of substituted pyrrolo[2,3-c]pyridine-7-ones is developed that applies an acid-promoted intramolecular cyclization of 2-pyrrolecarboxylic acid amidoacetals as key step. The synthesis is easily scaled up to 1.5 mol quantity with no yield decrease. The alkylation/arylation reaction of the pyrrolo[2,3-c]pyridine-7-ones proceeds regioselectively giving N6-substituted derivatives.

Nechayev M.; Gorobets N.; Borisov A.; Kovalenko S.; Tolmachev A.
Mol. Diver. 2012, 16 (4), 749-757
DOI: 10.1007/s11030-012-9410-1