Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles

Eur. J. Org. Chem. 2017, (41), 6114-6120

DOI: 10.1002/ejoc.201700803

Lebed P.; Fenneteau J.; Wu Y.; Cossy J.; Mykhailiuk P.
N-Nitroso CHF2-pyrazolines were synthesized from in situ generated difluoromethyldiazomethane (CF2HCHN2), tert-butyl isonitrite (tBuONO), and alkenes. The synthesis of representative CHF2-pyrazoles and CHF2-oxazolines was also performed.


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