More

Phenyl(trifluoromethyl)mercury

Current reagent is an effective and facile generator of difluorocarbene. Phenyl(trifluoromethyl)mercury is a stable, crystalline solid which releases CF2 under mild, nonbasic reaction conditions. The compound is hydrolytically stable and can be handled under standard laboratory conditions. The reaction of PhHgCF3 and 3 molar equiv of anhydrous sodium iodide in benzene medium in the presence of olefins serves excellently in the synthesis of gem-difluorocyclopropanes. High products yields could be obtained in reaction times of about 15hr at 80-85°C.

Few examples are given on Scheme.


References: Seyferth D., Hopper S. P. // J. Org. Chem., 1972, 37, p. 4070-4075
Haas A., Hinsken W. // J. Fluorine Chem., 1985, 28, p. 303-318

The reaction is stereospecific producing cyclopropanes with desired stereochemistry from the corresponding cis- or trans- alkenes.

Realizing value of the reagent we manufactured we have to offer it to our customers. To order material, receive technical information or suggest potential new products, please contact Enamine staff.

FOLLOW US

Contact us

Send a message