Nucleoside Mimetics
271 compounds
Nucleoside mimetics from 2.2M HTS Compound Collection
- Careful Substructure Search Search of nucleoside core fragments and their bioisosteric heterocycles with simultaneous presence of sugar-like moiety
- Strict MedChem Filters Removal of undesired functionalities, reactive groups and large aromatic fragments
- Chemotype Control Compounds with trivial structural fragments were mostly removed. Control of renovation of the library in accordance to new literature data.
Design of REAL Nucleoside mimetics dataset
REAL structures with validated synthetic procedures
- Combinatorial approach Over 100 000 Building Blocks immediately available for modification:
- Diazine heterocyclic cores mimic nucleobases
- alicyclic amino alcohols - sugars
- Filtering of unwanted functionalities & MedChem inspection
- Automated parallel synthesis Implementation of well-developed reaction procedures operated by highly experienced staff
Design of REAL Nucleoside mimetics dataset
