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Nucleoside Mimetics

Small library of specially synthesized compounds

290 compounds

Mimetics of nucleosides are special class of proven therapeutic agents, which already showed high efficacy in treatment of viral infections, cancer and bacterial disease. In spite of similar structural motifs and common moieties and even cores, many modified nucleosides display high selectivity to certain class of targets. This type of molecules is well-tunable when using at least two sites of possible modification. Recently, we developed few alternative parallel chemistry approaches to make these compounds more accessible within reasonable time and in cost-effective manner. Using our library for your hit finding you receive multiple benefits:

  • Well-validated chemistry and guaranteed resynthesis of identified hits.
  • Straightforward & low-cost synthesis of follow-up libraries through our REAL Database technology.
  • Medicinal chemistry support enhanced with on-site broad ADME/T panel.

Most popular library formats

Catalog No.
Compounds
Plates
Amount
Format
Price

Catalog No.

NML-290-Y-0

Compounds

290

Plates

1

Amount

≤ 300 nL of up 2mM DMSO solutions

Format

384-well microplates, 320 compounds per plate, first two and last two columns empty

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Request a quote

Catalog No.

NML-290-X-20

Compounds

290

Plates

4

Amount

20 µL of 10 mM DMSO stock solutions

Format

963-well plates, (Greiner Cat. No 650160), 80 compounds per plate, 1 & 12 columns empty

Request a quote

Request a quote

Catalog No.

NML-290-X-50

Compounds

290

Plates

4

Amount

50 µL of 10 mM DMSO solutions

Format

96-well plates (Greiner Cat. No 650201), 80 compounds per plate: 1 & 12 columns empty

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Request a quote

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

Library Design

  • Careful Substructure Search
    Search of nucleoside core fragments and their bioisosteric heterocycles with simultaneous presence of sugar-like moiety
  • Strict MedChem Filters
    Removal of undesired functionalities, reactive groups and large aromatic fragments
  • Chemotype Control
    Compounds with trivial structural fragments were mostly removed. Control of renovation of the library in accordance to new literature data.

Design of REAL Nucleoside mimetics dataset

REAL structures with validated synthetic procedures

  • Combinatorial approach
    Over 100 000 Building Blocks immediately available for modification:
    • Diazine heterocyclic cores mimic nucleobases
    • alicyclic amino alcohols - sugars
  • Filtering of unwanted functionalities & MedChem inspection
  • Automated parallel synthesis
    Implementation of well-developed reaction procedures operated by highly experienced staff

Design of REAL Nucleoside mimetics dataset

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