Ready-to-use sets to support your discoveries
We at Enamine are constantly working on creating novel molecules and innovative synthetic pathways for the Drug Discovery Community. We carefully designed and synthesized a series of E3 binders with attached linkers of different lengths and natures to support Degrader Research and Development. One of our recent focuses is the derivatization of the von Hippel-Lindau (VHL) Cullin RING E3 ligase binders.
Our kits provide a robust selection of pre-synthesized VHL ligands (VHL 032, Me-VHL 032, VHL 101-phenol, and VHL 285-phenol) conjugated to linkers with varying lengths and compositions. This comprehensive offer goes beyond standard PEG- and Carba-linkers, including rigid/cyclic linkers proven effective in bifunctional molecule design.
Linker’s terminal functional groups can be easily modified through the most straightforward reactions – amide coupling or click-chemistry.
Product catalog
Product name
VHL Amine Kit-1
Amine-1-227
Description
VHL 032 and Me-VHL 032 derivatized with most comprehensive and diverse linkers of variable length from 2 to 18 heavy atoms in a chain with terminal amine functional group
Key features
- Easy access, ready for delivery in plates as 20 mM solutions in DMSO
- Variation VHL ligand
- Variable in length from 4 up to 18 heavy atoms
- Well-balanced composition including PEG-, Carba- and Rigid-linkers
