Fluorine-containing amino acids play a crucial role in modulating molecular polarity, volume, stabilizing specific conformations, and adjusting pKa providing invaluable support in the design of drugs and peptidomimetics. Our team of skilled chemists specializes in synthesizing cutting-edge fluorinated amino acids, with a significant number exclusively offered through Enamine. These novel compounds are frequently incorporated into our inventory even before their publication.
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Over 100 fluorine-containing amino acids from stock on 5-10 gram scale.
Cyclic molecular skeletons are widely applied in the construction of medicinal molecules due to their ability to occupy binding pockets and impose conformational restrictions. Among these structures, symmetric forms like cubane and adamantane have been prevalent. In exploring their creative potential, Enamine chemists have prepared a panel of non-classical 3D-shaped cyclic scaffolds capable of occupying intermediate molecular volumes and lipophilicity values.
Concept
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Over 50 non-classical 3D-shaped compounds from stock on 5-10 gram scale.
Speed, Quality, and Novelty
Advancements of new technologies and promising discoveries is progressing faster and more intensively with each passing day. Therefore, Enamine, a global leader in the chemical building block market, has developed a special product - the Fast MADE Building Blocks. This is a special set of Enamine MADE (MAke-on-DEmand) building blocks (BBs) that will be synthesized and delivered to our customers in ultra-short terms.
Such compounds are synthesized within 7‑10 days, through 1-3 commonly utilized procedures (Amidation, heterocyclization, arylation, Grignard reaction, reductive amidation, etc.) with a very high success rate (more than 80%). They are readily available through proven synthetic protocols using our in stock building blocks. It takes just 2‑3 weeks from the moment of the order to deliver to our customers.
Well-validated synthesis protocols and the availability of a large amount of various starting raw materials in stock (above 300,000 BBs in gram quantities and 10,000 BBs in quantities > 1 kg), allow us quickly and easily synthesize more than 90M Fast MADE Building Blocks.
Our highly qualified and experienced specialists are constantly working to ensure that the set of the Fast MADE Building Blocks continues to grow, and synthesis protocols are being improved.
The jointly acquired broad experience now allows us to offer our customers a large number of diverse compounds. Almost all the compounds are novel, and not available through other suppliers. The Fast MADE includes diverse classes of chemical compounds, such as alcohols, primary and secondary amines, amides, sulfonyl chlorides, halides, carboxylic acids, etc.
Key Facts:
- Your ordered compounds and compound sets will be synthesized and delivered to you within a period of up to 2‑3 weeks;
- In-stock availability of raw materials directly at Enamine enabling immediate start of the synthesis;
- Well-developed, standardized, and improved synthesis protocols allow us to obtain targeted Building Blocks with very high success rates (more than 80%) in the shortest possible time;
- All of our chemical building blocks undergo extensive quality control by NMR and LC-MS, and purity is guaranteed to be over 95%.
You can conveniently make an online substructure or similarity search for novel, previously unseen compounds at our partner website: https://chem-space.com/search, the only online resource that has the comprehensive and most up-to-date collection of Fast MADE Building Blocks.
Molecular Properties
Cationic amino acids enhance the transport and binding of peptide structures to proteins and serve as molecular scaffolds in small molecule design. Their analogues impose conformational restrictions onto otherwise flexible side-chains. In addition, they help modulate the electronic properties of the amino groups and their pKa values. Enamine library of cationic amino acids is exceptionally rich, offering various skeletons and protecting group patterns.
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Over 100 cationic amino acids from stock on 5-10 gram scale.
Introduced in 2016 as reagents for the synthesis of cyclobutyl amines and thiols, bicyclobutanes have emerged as excellent precursors for organic transformations as well as substituents in medicinal molecules. The compounds are bench-stable materials, however, the intrinsic strain of the bicyclic skeleton makes them reactive in nucleophilic addition, cycloaddition, and insertion reactions. In biological settings, bicyclobutanes are particularly reactive towards cysteine residues, creating an alternative to maleimide for covalent binding. Following the rising demand for their use in organic reactions, Enamine chemists have prepared a library of bicyclobutanes for exploring innovative chemical reactions.
Reactions
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Over 20 bicyclobutanes from stock on 5-10 gram scale.
