The LARGEST catalog in the world
Enamine is a renowned leader in the market of building blocks. Our stock collection counts 300 000 building blocks on a gram scale, most of which being unique – not available from other suppliers. These compounds have been synthesized in-house and in collaboration with FCH Group, Intermed Chemicals, and UORSY.
The jointly acquired broad experience now allows us to offer 1.35B MADE (MAke-on-DEmand) Building Blocks. Prices are assigned to each compound proving solid scientific basis and assuring our confidence in their synthesis. It is by far the world’s largest and most comprehensive catalog of all commercially available building blocks with less than 20 effective heavy atoms (not counting protecting groups)! Most of the compounds are novel, not available through other suppliers or other global aggregate platforms. MADE Building Blocks include such popular in medicinal chemistry compound classes as primary and secondary amines, sulfonyl chlorides, boronic acids, carboxylic acids, alkynes, azides, etc.
In the ocean of virtual and me-too compound catalogs, we offer our proven high-end synthesis expertise to deliver our MADE Building Blocks because of:
- Thoroughly documented synthesis protocols (2-4 steps only!) allowing the trouble-free synthesis of next compounds
- In-stock availability of raw materials (incl. ca. 10 000 building blocks in > 1 kg) directly at Enamine enabling immediate synthesis start
Every month, our chemists synthesize around 2 000 new MADE Building Blocks on our customers’ orders. The synthesis typically takes 2-6 weeks and has > 76% success rate.
You can conveniently make an online substructure or similarity search for novel, previously unseen compounds at our partner Chemspace website: https://chem-space.com/search, the only online resource having the comprehensive and most up-to-date collection of MADE Building Blocks.
The MADE Building Blocks are also marketed under brands of FCH Group, and Intermed Chemicals, and UORSY.
Molecular properties
Bifunctional DEL-compatible scaffolds
Other classes include:
Carboxylic acid - Aryl halide (in stock / feasible)N-Boc-Amino acid (in stock / feasible)
NCbz-Amino acid (in stock / feasible)
Carboxylic acid - Isothiocyanate (in stock / feasible)
Aldehyde - N-Boc-Amine (in stock / feasible)
Aldehyde - Sulfonyl halide (in stock / feasible)
Amine - Ester (in stock / feasible)
Azide - Sulfonyl halide (in stock / feasible)
Amine - N-benzyl amine (in stock / feasible)
Amine - N-Boc-Amine (in stock / feasible)
Amine - N-Cbz-amine (in stock / feasible)
Amine - N-Fmoc-amine (in stock / feasible)
Ester - Isocyanate (in stock / feasible)
Ester - Sulfonyl halide (in stock / feasible)
Functional boronates (in stock / feasible)
Carboxylic acid - Terminal Alkyne (in stock / feasible)
Carboxylic acid - Nitro (in stock / feasible)
Aldehyde - Ester (in stock / feasible)
Aldehyde - Nitro (in stock / feasible)
Aldehyde - Azide (in stock / feasible)
Azide - Aryl halide (in stock / feasible)
Carboxylic acid - Azide (in stock / feasible)
Aryl halide - Terminal Alkyne (in stock / feasible)
Aryl halide - Aryl halide (in stock / feasible)
Trifunctional DEL-compatible scaffolds
Other classes include:
Carboxylic acid - Aldehyde - Nitro (in stock / feasible)Carboxylic acid - Aryl halide - Ester (in stock / feasible)
Carboxylic acid - Aryl halide - Nitro (in stock / feasible)
Carboxylic acid - Ester - Nitro (in stock / feasible)
Amine - Aryl halide - Nitro (in stock / feasible)
Terminal Alkyne - N-Boc-amino acid (in stock / feasible)
Aryl halide - N-Boc-amino acid (in stock / feasible)
Nitro - N-Boc-amino acid (in stock / feasible)
N-Boc-N'-Cbz-diamino acid (in stock / feasible)
Aryl halide - N-Fmoc-amino acid (in stock / feasible)
Ester - N-Fmoc-amino acid (in stock / feasible)
Nitro - N-Fmoc-amino acid (in stock / feasible)
Amine - Aryl halide - Aryl halide (in stock / feasible)
Amine - N-Boc-Amine - Aryl halide (in stock / feasible)
Aryl halide - Aryl halide - Aryl halide (in stock/ feasible)
Carboxylic acid - Aryl halide - Aryl halide (in stock)
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The current virtual database includes 175M of bifunctional and 2.5M of trifunctional building blocks. All molecules in this space are feasible for synthesis with high predicted success rate, since their enumeration is based on previously acquired validated experimental data. Additionally, custom synthesis of specific core-structures for the Customer’s needs are also possible and could be performed on both FFS and FTE base. Our team of experienced Synthetic Organic Chemists can deliver new desired molecules at competitive prices in short lead time.
The on-DNA synthesis of functionally diverse pyridazines based on inverse-electron-demand Diels-Alder (IEDDA) reactions of 1,2,4,5-tetrazines has been shown recently. Herein we propose tetrazine-derived compound library designed for DNA ligation and DNA-compatible IEDDA reactions. See also: "Structurally optimized tetrazines for rapid biological labeling"
Enamine designs, develops and synthesizes chemical reagents, scaffolds and intermediates widely known as building blocks for their convenient use in medicinal chemistry and synthesis of combinatorial compound libraries. Our catalog has 2 367 670 diverse building blocks of various chemical classes that make it the largest and most abundant source of research chemicals in the world.
Other classes of building blocks:
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Enamine designs, develops and synthesizes chemical reagents, scaffolds and intermediates widely known as building blocks. They are convenient for using in medicinal chemistry and synthesis of combinatorial compound libraries.
Our catalogue currently contains 2 367 670 building blocks including 300 000 compounds in stock, which can be delivered within 1-7 days from our global logistics centers in the USA and Europe, and via our official distributors in Asia and Oceania. To date, Enamine collection is the largest and most abundant single source of medchem building blocks in the world
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Key Facts:
- Most building blocks are available from stock in 1-5 g amounts.
- At EnamineStore.com you can find up-to-date prices, availability, and lead times for most of the building blocks in stock and for synthesis.
- All of our chemical building blocks undergo extensive quality control by NMR and LC-MS, and purity is guaranteed to be over 95%.
- You can download MSDS and CoA for most of the building blocks here.
Below is a diagram showing stock composition by classes of building blocks:
You can browse and purchase our building blocks at our online shop EnamineStore. There you will get up-to-date price, availability, and lead time information.
Each month our catalogue is enriched with over 1 500 new building blocks. You can be among the first to discover these innovative molecules by subscribing to our Catalogue Update Letters. Each of these monthly updates will bring you around 60 carefully selected, most interesting structures of building blocks that are available for immediate purchase from our stock.
Services
Enamine offers world class service in chemical synthesis of a wide variety of organic compounds on the milligram to kilogram scale at competitive price.
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
