TIPS triflate

CAS 80522-42-5, Cat. No EN300-6762257
Reagent for silylation

EnamineStore

Triisopropylsilyl trifluoromethanesulfonate (TIPS triflate) is a highly reactive silylating reagent and Lewis acid, primarily used for the protection of alcohols, ketones, and lactones by forming triisopropylsilyl ethers¹. Its scope includes protecting terminal alkynes, forming enol silyl ethers, and promoting conjugate additions in organic synthesis. TIPS triflate is also applied to synthesizing (triisopropylsilyl)diazomethane in obtaining silyl-substituted nitrilimines. This colorless oil is moisture-sensitive and should be stored under an inert atmosphere at low temperatures (0°C) due to its rapid reaction with water and protic solvents.

Synonyms: triisopropylsilyl triflate; triisopropylsilyltrifluoromethanesulfonate; TIPS triflate; TIPSOTf; trifluoromethanesulfonic acid triisopropylsilyl ester; triisopropylsilyl trifluoromethanesulphonate; tri(propan-2-yl)silyl trifluoromethanesulfonate