TFEF

CAS 32042-38-9, Cat. No EN300-7592173
Reagent for N/O-formylation

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2,2,2-Trifluoroethyl formate (TFEF) is a versatile reagent that enables N- and O-formylating of alcohols, amines, and N-hydroxylamines in soft conditions¹. It is a colorless shelf-stable liquid, but highly flammable. The reaction of formylating alcohols can be carried with primary, secondary, and tertiary alcohols (but with tertiary the yield is lower, but still moderate). The formylating of primary and secondary amines is faster than O-formylating and generally gives an excellent yield. In the case of amino alcohols, the reagent prefers an amino group. Also, the reagent formylates N-hydroxylamines with high yields (88–95%) making this reagent an indispensable instrument.

Synonyms: 2,2,2-trifluoroethyl formate; trifluoroethyl formate; formic acid 2,2,2-trifluoroethyl ester; 2,2,2-trifluoro-ethanol-1-formate