Selectfluolor

CAS 140681-55-6, Cat. No EN300-98145
Reagent-donor of electrophilic Fluorine

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Selectfluor is a highly stable and practically nonhygroscopic crystalline solid, representing a significant advancement in electrophilic fluorinating agents. Unlike traditional reagents that require special handling and pose potential hazards, Selectfluor offers exceptional safety and ease of use^[1]. Being a dication, Selectfluor is soluble in a select few polar solvents, including acetonitrile, N, N-dimethylformamide (DMF), water, and nitromethane. The versatility of Selectfluor is remarkable, with a wide scope of applications. It serves as a powerful electrophilic fluorine donor, enabling α-fluorination of carbonyl functionalities, as well as the fluorination and oxidation of thioethers^[2]. Additionally, it plays a key role in the synthesis of glycosyl fluorides and the fluorination of alkenes and aromatic compounds. Moreover, Selectfluor showcases oxidation capabilities, allowing for the oxidation of benzylic alcohols and tertiary carbon centers^{[1], [2]}. This broad range of applications makes Selectfluor an indispensable reagent and a universal tool in synthetic chemistry.

Synonyms: 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium, bis(tetrafluoroboranuide), 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate, F-TEDA-BF