Oxyma

CAS 3849-21-6, Cat. No EN300-17466
Additive in peptide bond formation

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Ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma) is an additive to carbodiimides in peptide bond formation with a similar reactivity as triazoles and prevents epimerization¹. The advantage of Oxyma is that it is very stable and doesn’t have an explosion risk like triazole, and it is more effective than HOBt or HOAt. The compound is a white crystalline stable solid, soluble in DMF, NMP, MeCN, DCM, and H₂O, partially in toluene. The additive has been shown to have the same effectiveness in solid-phase peptide and classical synthesis.

Synonyms: Eethyl 2-cyano-2-(hydroxyimino)acetate; ethyl cyano(hydroxyimino)acetate; Oxyma Pure/p>