N-Bromoacetamide

CAS 79-15-2, Cat. No EN300-7394435
Reagent for alkenes bromohydration

EnamineStore

N-Bromoacetamide (NBA) is an effective reagent for bromohydration and bromofluorination of alkenes. It is stable white needle-like crystals, soluble in various solvents such as CHCl₃, H₂O, and THF. The standard conditions for bromination reactions typically involve adding NBA to a solution of the alkene in aqueous acetone, dioxane, or THF mixtures at low temperatures (~ 0℃). However, the reaction conditions can be modified to yield different products. For instance, conducting the reaction in acetic acid can lead to the formation of bromoacetates, while employing anhydrous HF in ether allows the synthesis of 1,2-bromofluorides. The bromofluorination method has found significant utility in synthesizing various compounds, including fluorinated steroids, fluoro amino acids, and other fluorine analogs of bioactive molecules.¹

Synonyms: acetamide, N-bromo-(ACI); acetobromamide; NBA