Mukaiyama reagent

CAS 14338-32-0, Cat. No EN300-21556
Reagent for carboxylic acid activation

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Mukaiyama reagent is a versatile tool in carboxylic acids chemistry, that facilitates the formation of esters and amides, lactones, ketene, and β-lactams^1,2. It is a hygroscopic yellow solid, bench-stable that is easy to work with. The reagent is soluble in most organic solvents, but the best for the reaction is DCM¹. The reason is that the co-product from the reaction is insoluble in DCM and precipitates from the solvent². Good results are obtained even for hindered carboxylic acids and alcohols. Analogous, the reaction works well for amide synthesis¹. This method can be used for, lactones and β-lactams synthesis. If a carboxylic acid contains a suitably placed alkene, the resulting ketene can undergo intramolecular [2 + 2] cycloaddition to yield ketene¹.

Synonyms: 2-chloro-1-methylpyridinium iodide