Koser’s reagent

CAS 27126-76-7, Cat. No EN300-113070
Reagent for oxidation, oxytosylation and phenyliodination

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[Hydroxy(tosyloxy)iodo]benzene (HTIB) is a versatile reagent for mild oxidation. It is a white solid, which may be stored at room temperature, but it is better to keep it refrigerated and in a dark bottle¹. Reagent is moderately soluble in H₂O, MeOH, DMSO, and insoluble in Et₂O, CH₂Cl₂, and CHCl₃. Although HTIB is largely insoluble in DCM or chloroform, both are excellent solvents for the transformations, because the completion of the reaction can be visible when all solid phases disappear². The reagent is employed in the α-oxidation of carbonyl compounds, oxidation of olefins, ring contractions and expansions, dearomatization of phenols, and synthesis of iodonium salts^1,2.

Synonyms: HTIB; [hydroxy(tosyloxy)iodo]benzene; phenyliodine(III) (hydroxyl)tosylate