Ethyl bromodifluoroacetate

CAS 667-27-6, Cat. No EN300-39190
Reagent for difluoroalkylation

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Ethyl bromodifluoroacetate is a versatile electrophilic reagent used for difluoroalkylation in organic synthesis¹. It enables copper-mediated C–C coupling with alkenyl boronates, providing an efficient route to gem-difluorinated allyl acetates². This reaction operates under mild conditions using copper powder and TMEDA, offering an alternative to traditional Suzuki couplings. The reagent is valuable for pharmaceutical and synthetic chemistry, producing CF₂-functionalized building blocks with high efficiency. This moisture-sensitive liquid should be stored under an inert atmosphere to prevent hydrolysis. The method is scalable up to 76g, making it practical for large-scale applications.

Synonyms: ethyl 2-bromo-2,2-difluoroacetate; ethylbromodifluoroacetate; bromodifluoroacetic acid ethyl ester; ethyl difluorobromoacetate; acetic acid, bromodifluoro-, ethyl ester; 2-bromo-2,2-difluoroacetic acid ethyl ester; ethyl bromodifluoroacetate