Diethyl cyanomethylphosphonate

CAS 2537-48-6, Cat. No EN300-55952
Reagent for Wittig reaction

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Diethyl cyanomethylphosphonate is a modified Witting reagent that allows the synthesis of α,β-unsaturated nitriles. It is an oil, soluble in THF, DME, and DCM¹. The stereochemistry of the α,β-unsaturated nitriles is variable depending on the substrate and the reaction conditions1. In general, the properties of the reagent are similar to other Wittig reagents.

Synonyms: (cyanomethyl)diethoxyphosphine oxide; (cyanomethyl)phosphonic acid diethyl ester; (diethoxyphosphinyl)acetonitrile; (diethoxyphosphono)acetonitrile; (diethylphosphono)acetonitrile; 2-(diethylphosphonyl)acetonitrile; 2-diethoxyphosphorylacetonitrile; diethyl (cyanomethyl)phosphonate; diethyl cyanomethanephosphonate; diethyl cyanomethylphosphonoacetat