Carbonyldiimidazole

CAS 530-62-1, Cat. No EN300-21023
Reagent for activation of carboxylic acids

EnamineStore

Carbonyldiimidazole (or CDI) is a classical reagent for the activation of carboxylic acids¹. The reagent is white solid, and shelf-stable but is moisture sensitive and reacts with water to produce CO₂. It is well soluble in THF, benzene, CHCl₃, and DMF, but solvents must be dehydrated before usage. Beyond the synthesis of esters and amides, the reagent may be used as a direct replacement for the highly toxic phosgene in reactions with alcohols and amine.

Synonyms: N,N′-Carbonyldiimidazol, CDI