t-Butyl 2,2,2-trichloroacetimidate

CAS 98946-18-0, Cat. No EN300-100400
Reagent for t-butyl ester- and etherification

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tert-Butyl 2,2,2-trichloroacetimidate is a reagent for synthesizing t-butyl esters and ethers in soft conditions with high yields¹. It is a white solid soluble in organic solvents, preferably nonpolar ones, especially cyclohexane. Polar solvents promote ionization and decomposition of the reagent. In the reaction of ether formation, a less hindered hydroxy group is preferable, and in the case of secondary alcohols - 2 equivalent of reagent is needed for a more effective reaction. After the purification procedure, the reaction yield is about 80‑90%.

Synonyms: 2,2,2-trichloroacetimidic acid tert-butyl ester; 2,2,2-trichloroethanimidic acid tert-butyl ester; O-tert-butyl trichloroacetimidate; tert-butyl 2,2,2-trichloroacetimidate; tert-butyl 2,2,2-trichloroethanimidate; tert-butyl trichloroacetimidate