An improvement on Yarovenko's reagent, Ishikawa's Reagent is shelf-stable and has proven to be a valuable addition to the arsenal of chemists working in the field of fluorination. It is easy to work with white powder that allow soft conversion of alcohols into alkyl fluorides, carboxylic acids into acyl fluorides and in the preparation of 2,3,3,3-tetrafluoropropionate esters and other fluorine-containing carbonyl compounds. Additionally, it serves as a key reagent in the synthesis of α-Fluoro-α-(trifluoromethyl)-ɣ,σ-unsaturated amides from allylic alcohol. Beyond its classical fluorination capabilities, Ishikawa's Reagent finds applications in the formation of iminium phosphate salts from phosphanes and phosphoranes.
Synonyms: PPDA, N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine, Hexafluoropropene Diethylamine