Sulfoximines
Introduction of a sulfoximine group has been found as an utile approach in medicinal chemistry to improve ADME/Tox profile and to enhance potency of the biologically active compounds. The sulfoximine fragment is chemically and metabolically stable; additionally, NH-sulfoximines can serve as both hydrogen bond donors and acceptors at the same time. This makes sulfoximine-derived building blocks appealing for modern drug discovery.
Properties
- stable to hydrolysis
- increases aqueous solubility
- can be modified at NH
- NH-sulfoximines serve as H-bond donors and acceptors
Our offer:
>200 Sulfoximine building blocks in gram amounts in stock. Custom synthesis of further analogues and compound libraries
MedChem Highlights
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks for Drug Design
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Diazirines