Introduction of a sulfoximine group has been found as an utile approach in medicinal chemistry to improve ADME/Tox profile and to enhance potency of the biologically active compounds. The sulfoximine fragment is chemically and metabolically stable; additionally, NH-sulfoximines can serve as both hydrogen bond donors and acceptors at the same time. This makes sulfoximine-derived building blocks appealing for modern drug discovery.


  • stable to hydrolysis
  • increases aqueous solubility
  • can be modified at NH
  • NH-sulfoximines serve as H-bond donors and acceptors

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>200 Sulfoximine building blocks in gram amounts in stock. Custom synthesis of further analogues and compound libraries

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