Diazirine is a smallest heterocycle that is stable in the dark, but forms reactive carbene upon irradiation with light. Its introduction into the structures of biologically active compounds accompanying with only minor change in MW (plus only 2 nitrogen atoms!) has proven to provide efficient tools to study interactions with biological targets including their isolation and identification. Given the success and progress in the field of activity-based protein profiling, the use of diazirine photolabeling will most likely continue to rise and it is important to have a commercial access to diverse diazirine-containing building blocks.
- smallest photoreactive group
- excitation at 355 nm
- high chemical stability
Upon irradiation of a ligand-target complex, a diazirine-containing ligand generates a reactive carbene that covalently binds the ligand to the target.
Our offer: >30 building blocks from stock.
Custom synthesis of the diazirine building blocks and diazirine-containing ligands.
- Building blocks and linkers for PROTAC synthesis
- Heterocyclic Sulfonyl Fluorides
- Silicon-Containing Building Blocks
- Epoxides for Drug Design
- Analogues of CF3-Pyridine for Drug Design
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks for Drug Design
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Oxetane-containing Building Blocks
- SF5-Building Blocks
- Stannanes for coupling reactions
- Sulfoximines for Drug Design
- Saturated Bioisosteres of Benzene
- Heterocyclic scaffolds
- Azide-linkers for Drug Design
- Unnatural Amino Acids
- Cubane-containing building blocks
- Benzoxaboroles for Drug Design