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Recent News
11 April 2024
Press Release
Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
Synthesis 2015, 26 (08), 1123-1130
DOI: 10.1055/s-0034-1380116
Ivon Y. M.; Tymtsunik A. V.; Komarov I. V.; Shishkin O. V.; Grygorenko O. O.
The synthesis of optically pure (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-1-carboxylic acid starting from easily available ‘chiral pool’ L-4-hydroxyproline is reported. A tandem Strecker reaction–intramolecular nucleophilic cyclization (STRINC) sequence was used as the key synthetic step for the first time to prepare a diamino acid. Careful examination of the side products obtained in the STRINC step allowed the suggestion of a mechanistic explanation for the observed facts and optimization the yield of the aminonitrile precursor. The reported scalable synthesis opens the way to use the diamino acid as a branch point in peptides and as a building block in drug discovery.