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  • Influence of the Synthesis Conditions and the Presence of Guest Molecules on the Structures of Coordination Polymers [Fe2MO(Piv)6(L) x ] n (L = 4,4′-Bipyridine, Bis(4-Pyridyl)ethane) with the Labile Crystal Lat

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones

ACS Comb. Sci. 2015, 17 (6), 348-354

DOI: 10.1021/acscombsci.5b00024

Bogolubsky A. V.; Moroz Y. S.; Mykhailiuk P. K.; Ostapchuk E. N.; Rudnichenko A. V.; Dmytriv Y. V.; Bondar A. N.; Zaporozhets O. A.; Pipko S. E.; Doroschuk R. A.; Babichenko L. N.; Konovets A. I.; Tolmachev A.

A simple and cost-effective one-pot parallel synthesis approach to sulfides, sulfoxides, and sulfones from thiourea was elaborated. The method combines two procedures optimized to the parallel synthesis conditions: alkylation of thiourea with alkyl chlorides and mono or full oxidation of in situ generated sulfides with H2O2 or H2O2-(NH4)2MoO4. The experimental set up required commonly used lab equipment: conventional oven and ultrasonic bath; the work up includes filtration or extraction with chloroform. The method was evaluated on an 81 member library of drug-like sulfides, sulfoxides, and sulfones yielding the compounds on a 30-300 mg scale. A small-scale synthesis of 2-(benzhydrylsulfinyl)acetamide (modafinil) utilizing our approach resulted in similar efficiency to the published procedures.

One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones

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