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Trifluoromethyl-Substituted Analogues of 1-Aminocyclobutane-1-carboxylic Acid

Synlett , 2009,11, 1827-1829

DOI: 10.1055/s-0029-1217355

Radchenko D. S.; Mykhailiuk P. K.; Bezdudny A. V.; Komarov I. V.

Trifluoromethyl-substituted analogues of the 1-amino-cyclobutane-1-carboxylic acid - 1-amino-3-(trifluoromethyl) cyclobutanecarboxylic and 1-amino-3,3-bis(trifluoromethyl)cyclobutanecarboxylic acids - have been synthesized from 1,3-dibromoacetone dimethyl ketal. The key step of the syntheses is a transformation of the acid moiety into the trifluoromethyl group using SF4 and HF.

Trifluoromethyl-Substituted Analogues of 1-Aminocyclobutane-1-carboxylic Acid

Radchenko D. S.; Mykhailiuk P. K.; Bezdudny A. V.; Komarov I. V.
Synlett 2009, 11, 1827-1829
DOI: 10.1055/s-0029-1217355

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