Multigram Synthesis of Functionalized Spirocyclic Diazirines
Eur. J. Org. Chem. 2019, (23), 3744-3750
An approach to the synthesis of spirocyclic diazirines from cyclic ketones was examined on a series of carbo‐ and heterocyclic substrates containing the amine or carboxylic acid moiety. A mini‐library of stereochemically diverse functionalized spirocyclic diazirines was synthesized on a multigram scale with 30–81 % yield.