Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation
Eur. J. Org. Chem. 2019, (22), 3553-3559
Novel spirocyclic pyrrolidines were synthesized in three steps from cyclic α‐amino acids with 3‐ to 7‐membered cycle. The key transformation was the Dieckmann condensation reaction. The described approach opens a door to various novel spirocyclic building blocks for drug design.