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Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation

Eur. J. Org. Chem. 2019, (22), 3553-3559

DOI: 10.1002/ejoc.201801750

Fominova K.; Diachuk T.; Sadkova I.; Mykhailiuk P.

Novel spirocyclic pyrrolidines were synthesized in three steps from cyclic α‐amino acids with 3‐ to 7‐membered cycle. The key transformation was the Dieckmann condensation reaction. The described approach opens a door to various novel spirocyclic building blocks for drug design.

Synthesis of 2,2-disubstituted spirocyclic pyrrolidines by intramolecular Dieckmann condensation

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