J. Fluorine Chem. 2015, 175 73-83
DOI: 10.1016/j.jfluchem.2015.03.008
Kubyshkin V.; Kheylik Y.; Mykhailiuk P. K.
Three novel amines all possessing gem-difluorocyclopropane, secondary amino group and a fused aliphatic cycle were synthesized by difluorocyclopropanation of N-Boc protected enamides. The compounds were stable when amino group was blocked by protonation or acylation, but otherwise underwent fragmentation already at the room temperature. Chemical structure, physico-chemical properties and fragmentation mechanisms of the fluorinated amines are studied in details.