Generation of C₂F₅CHN₂ In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

The novel chemical reagent, C₂F₅CHN₂, is generated in situ from C₂F₅CH₂NH₂⋅HCl and sodium nitrite. It reacts with mono- and disubstituted electron-deficient alkenes at oom temperature to afford C₂F₅-pyrazolines in excellent yields.

Mykhailiuk P. K.
Chem. Eur. J. 2014, 20 (17), 4942-4947
DOI: 10.1002/chem.201304840