Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State ¹⁹F NMR Spectroscopy

Designer label: A novel α-amino acid was designed as a conformationally restricted analogue of phenylalanine. It was synthesized and incorporated into the representative membrane-active peptide Magainin 2, to demonstrate its suitablility for structure analysis in oriented membranes by solid-state ¹⁹F NMR spectroscopy.

Tkachenko A. N.; Radchenko D. S.; Mykhailiuk P. K.; Afonin S.; Ulrich A. S.; Komarov I. V.
Angew. Chem. Int. Ed. 2013, 52 (25), 6504-6507
DOI: 10.1002/anie.201301344