Design and Synthesis of Novel ¹⁹F-Amino Acid: A Promising ¹⁹F NMR Label for Peptide Studies

Novel aliphatic ¹⁹F-substituted amino acid was designed as a ¹⁹F NMR label for peptide studies. The synthesis was performed in 11 steps and 9% overall yield from a commercially available starting material. The key transformation was a decarboxylative fluorination of an aliphatic carboxylic acid with XeF₂ in C₆F₆.