Conformationally Rigid Trifluoromethyl-Substituted α-Amino Acid Designed for Peptide Structure Analysis by Solid-State ¹⁹F NMR Spectroscopy

The fluorinated amino acid l-CF₃-Bpg (see picture), which was specifically designed as a ¹⁹F NMR label for structure analysis of membrane-bound peptides, does not display the drawbacks of previously used labels. The amino acid can be readily incorporated into peptides and is particularly suitable as a substitute for Leu, Ile, and Met.

Mikhailiuk P. K.; Afonin S.; Chernega A. N.; Rusanov E. B.; Platonov M. O.; Dubinina G. G.; Berditsch M.; Ulrich A. S.; Komarov I. V.
Angew. Chem. Int. Ed. 2006, 45 (34), 5659-5661
DOI: 10.1002/anie.200600346