An approach to dihydroisoindolobenzodiazepinones—three-dimensional molecular frameworks

A concise two-step procedure is developed for the preparation of dihydroisoindolobenzodiazepinones, which represent derivatives of three-dimensional molecular frameworks derived from classical privileged structures of medicinal chemistry. The method commences from the readily available starting materials (i.e., 2-formylbenzoic acid, o-phenylenediamine, and various ketones) and enables the synthesis of the title compounds in 58–82% overall yields.

Yaremenko A. G.; Shelyakin V. V.; Volochnyuk D. M.; Rusanov E. B.; Grygorenko O. O.
Tetrahedron Lett. 2013, 54 (10), 1195-1197
DOI: 10.1016/j.tetlet.2012.12.065