An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine
Synthesis , 2012, 44 (08), 1152-1154
DOI: 10.1055/s-0031-1289711
Yarmolchuk V. S.; Bezdudny A. V.; Tolmacheva N. A.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.
trans-2-(Trifluoromethyl)cyclopropylamine was prepared on a multigram scale from readily accessible 4,4,4-trifluorobut-2-enoic acid in five steps. The key step was a high-yielding cyclopropane ring formation from 4,4,4-trifluorobut-2-enoic acid methoxymethyl amide under Corey-Chaykovsky reaction conditions.
Yarmolchuk V. S.; Bezdudny A. V.; Tolmacheva N. A.; Lukin O.; Boyko A. N.; Chekotylo A.; Tolmachev A. A.; Mykhailiuk P. K.
Synthesis 2012, 44 (08), 1152-1154
DOI: 10.1055/s-0031-1289711