On the regioselectivity of the reaction of cyanothioacetamide with 2-acetylcyclo-hexanone, 2-acetylcyclopentanone, and 2-acetyl-1-(morpholin-4-yl)-1-cycloalkenes
Chem. Heterocycl. Compd. , 2012, 48 (2), 309-319
DOI: 10.1007/s10593-012-0991-5
Dotsenko V. V.; Krivokolysko S. G.; Polovinko V. V.; Litvinov V. P.
It has been established that the interaction of cyanothioacetamide with 2-acetylcyclohexanone, 2-acetylcyclopentanone, or their enamines (2-acetyl-1-(morpholin-4-yl)-1-cycloalkenes) contrary to the literature data have a non-regiospecific character and leads to the formation of mixtures of 3-cyano-4-methyl-5,6-tri(tetra)methylenepyridine-2(1 H)-thiones and 3-cyano-6-methyl-4,5-tri(tetra)methylene-pyridine-2(1 H)-thiones with a predominance of the latter.
Dotsenko V. V.; Krivokolysko S. G.; Polovinko V. V.; Litvinov V. P.
Chem. Heterocycl. Compd. 2012, 48 (2), 309-319
DOI: 10.1007/s10593-012-0991-5