Facile Synthesis of 2-(2-Ethoxy-1,2-dioxoethyl)azoles
Synthesis , 2011, 10, 1633-1637
DOI: 10.1055/s-0030-1260003
Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Mykhailiuk P. K.; Zaporozhets O. A.; Tolmachev A. A.
C-Acylation of N-substituted imidazoles with ethyl oxalyl chloride in the presence of N,N-diisopropylethylamine as a base afforded 2-(2-ethoxy-1,2-dioxoethyl)imidazoles in 83-95% yield. Application of this synthetic protocol to thiazoles and triazoles led to the corresponding 2-ethoxy-1,2-dioxoethyl derivatives in 40-51% yield.
Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Mykhailiuk P. K.; Zaporozhets O. A.; Tolmachev A. A.
Synthesis 2011, 10, 1633-1637
DOI: 10.1055/s-0030-1260003