Simple and Efficient Procedure for a Multigram Synthesis of Both trans- and cis-1-Amino-2-(trifluoromethyl)cyclopropane-1-carboxylic Acid
Synthesis , 2010, 03, 443-446
DOI: 10.1055/s-0029-1217141
Artamonov O. S.; Mykhailiuk P. K.; Voievoda N. M.; Volochnyuk D. M.; Komarov I. V.
A simple and efficient procedure for the multigram synthesis of both (±)-trans- and (±)-cis-1-amino-2-(trifluoromethyl)cyclopropane-1-carboxylic acid was developed. The key step of the synthesis is the addition of 1-diazo-2,2,2-trifluoroethane to methyl 2-[(tert-butoxycarbonyl)amino]acrylate, followed by thermal decomposition of the resulting pyrazoline. Gram quantities of trans- and cis-1-amino-2-(trifluoromethyl)cyclopropane-1-carboxylic acid were easily prepared from l-serine in one synthetic run.
Artamonov O. S.; Mykhailiuk P. K.; Voievoda N. M.; Volochnyuk D. M.; Komarov I. V.
Synthesis 2010, 03, 443-446
DOI: 10.1055/s-0029-1217141