General and Scalable Approach to Trifluoromethyl-Substituted Cyclopropanes
J. Org. Chem. 2023, 88 (6), 3859-3870
CF3-cyclopropanes with aliphatic, aromatic, and even heteroaromatic substituents were prepared on a multigram scale by deoxyfluorination of cyclopropane carboxylic acids or their salts with sulfur tetrafluoride. For labile α-pyridine acetic acids, only the use of their potassium salts allowed to obtain the needed products. Derivatization of CF3--cyclopropanes into building blocks ready for direct use in medicinal chemistry was performed.