Functionalized 5-Amino-4-cyanoxazoles, their Hetero- and Macrocyclic Derivatives: Preparation and Synthetic Applications

An approach for the synthesis of new 5-amino-4-cyanoxazoles with carboxylate group at the C-2 position, connected to the heterocycle directly or through an aliphatic linker, was developed. This process features readily available starting materials, simple operations, and good to high yields. Wide synthetic applicability of the obtained compounds was also successfully demonstrated by further modifications.