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2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from March 2024
Recent News
11 April 2024
Press Release
Cambridge, UK and Kyiv, Ukraine, 11 April 2024: Metrion Biosciences Limited (“Metrion”), the specialist ion channel and cardiac safety screening contract research organisation (CRO) and drug discovery company, and Enamine Ltd (“Enamine”), the global leader in supplying small molecules and early drug discovery services, announced that Metrion has enhanced its High Throughput Screening (HTS) services with the addition of access to Enamine’s compound libraries.
27 March 2024
Press Release
March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.
01 March 2024
News
We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.
Eur. J. Org. Chem. 2015, 29, 6466-6471
DOI: 10.1002/ejoc.201500746
Chernykh A. V.; Radchenko D. S.; Chernykh A. V.; Kondratov I. S.; Tolmachova N. A.; Datsenko O. P.; Kurkunov M. A.; Zozulya S. X.; Kheylik Y. P.; Bartels K.; Daniliuc C. G.; Haufe G.
Hitherto unknown cis- and trans-3-alkyl- and 3-aryl-3-fluorocycobutylamines have been synthesised selectively from 3-oxocyclobutane carboxylic acid in six or seven steps. Comparison of their pKa and log D values with those of the fluorine-free parent compounds showed acidification by about 0.8 units, irrespective of the stereochemistry. This indicates that there are no through-space interactions between fluorine and the amino function – a conclusion that was supported by the results of X-ray analysis. Fluorinated trans-compounds were found to be more lipophilic (Δ log P ≈ 1) compared with the non-fluorinated analogues, whereas the difference was marginal for cis isomers.
