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Antibacterial Library

9 100 compounds

Comparison of the molecular properties of the known antibacterials with those of other drugs showed a huge difference in polarity of the molecules. Antibacterials tend to have much higher PSA when compared to drugs of similar surface area. Using filters of relative PSA > 35%, MW lower than 450 Da (14 HA), and ClogD 7.4 < 1 we prepared a library of compounds which structures were rich in ionizable moieties such as zwitterions, carboxylic groups, as well as in multiple pharmacophores: OH, -SO2NH2, -CONH2, and -NHCONH-.

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