REAL Space

Billions of make-on-demand molecules

The REAL Space comprises 15.5 billion make-on-demand molecules and is currently the largest offer of commercially available compounds. The REAL compounds in the Space are assembled via more than 185 well-validated parallel synthesis protocols applied to over 111 500 qualified reagents and building blocks. The synthetic protocols include standard and advanced one-pot procedures. They differ in the number of steps, type of purification, and compound handling, and therefore in the effort required to deliver the products. The REAL compounds derived from the standard (prefix "s_") and the advanced (prefix "m_") protocols have different price and synthetic feasibility, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it. for more details.

The REAL space is not an enumerated database in a general sense: all search results are generated on the fly if they possess the same features as the query. The Space is currently accessible via REAL Space Navigator. The Navigator is a chemoinformatics software developed jointly with BioSolveIT. REAL Space Navigator vast resource allows for efficient hit exploration: from finding previously unknown analogs to scaffold hopping. Instead of using a Tanimoto similarity metric, the Navigator employs pharmacophore-style features which are not tied rigidly to substructure patterns and are more related to the properties. Therefore, the tool provides an escape from the availability bias of current in-stock screening collections towards IP free areas.

Amazingly, but chemical space of 15.5 billion compounds is stored in an archive of merely a few hundred megabytes, and average search time on a standard PC is between 2 and 4 minutes. Simply download REAL Space Navigator → install & execute to explore 15.5 billion molecules within less than 5 minutes.

  • the compounds generated are virtual but they are REAL – readily accessible
  • synthesis time is 3-4 weeks with an average success rate of over 80%
  • 15.5 billion molecules: the world's largest, ultra-fast searchable chemical space
  • search time 2 to 4 minutes on average for a typical lead
  • exceptional scaffold hopping capabilities to explore IP free areas


Download REAL Space Navigator (Note that at least 4Gb of main memory are required):

Linux x64 |  Windows x64 |  macOS


REAL Space Navigator is super-easy to use. Yet, just in case, here is a little bit of help, as well as an introductory deck of slides.

REAL compounds


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