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Covalent Fragment Library

Diverse covalent warheads with balanced reactivity

8 000 compounds

Covalent chemical probes have become a hot topic in drug discovery within last few years. The impressive number of successful applications in protein drugability assessment and in investigation of enzymes functions brought aspiration to discovery of new covalent modifiers. However, further progress in this area is limited by availability of new covalent fragments with new structures and balanced molecular properties. We have recently elaborated parallel chemistry approaches to synthesis of new libraries encompassing covalent fragments of various classes.

Our Covalent Fragment Library has been designed to encompass diverse compounds within each class of covalent binders. You can acquire either the entire diversity of fragments, 8 000 compounds, or focus on specific class of covalent binders. The compounds have been plated at 100 mM concentration in DMSO and can swiftly be supplied in multiple formats including the following most popular options:

Catalog No.
Library
Plates
Amount
Format
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Catalog ID

CFL-8000-10-Y-100

Library

Covalent Fragment Library 8 000 compounds

No of plates

25

Amount

10 µL of 100 mM solutions in DMSO

Plates and formats

384-well plates (Greiner Cat. No 781280): 1,2 & 23,24 columns empty, 320 compounds per plate

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Catalog ID

ACR-1920-25-Y-20

Library

Acrylamide Library 1 920 compounds

No of plates

6

Amount

25 µL of 20 mM solutions in DMSO

Plates and formats

384-well plates (Greiner Cat. No 781280), 320 compounds per plate: 1,2 & 23,24 columns empty

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Catalog ID

CLA-1040-100-X-20

Library

Clroracetamide Library 1 040 compounds

No of plates

13

Amount

100 µL of 20 mM solutions in DMSO

Plates and formats

0.75 mL 2D barcoded V-bottom microtubes in latch racks (Matrix Cat. No 3731), 80 compounds per plate

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Catalog ID

SFF-320-10-Y-100

Library

Sulfonyl fluoride fragments 320 compounds

No of plates

1

Amount

10 µL of 100 mM solutions in DMSO

Plates and formats

384-well Echo qualified plates (Labcyte PP-0200): 1,2 & 23,24 columns empty, 320 compounds per plate

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Catalog ID

BAF-640-50-X-20

Library

Boronic acid fragments 640 compounds

No of plates

8

Amount

50 µL of 20 mM solutions in DMSO

Plates and formats

96-well plates (Matrix Cat. No 4271), 80 compounds per plate: 1 & 12 columns empty

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Please request for any other options. Please note that you can cherry pick from our Covalent Fragment Collection.

Key features

  • Careful choice of warheads: only experimentally confirmed reactivity reported in the literature!
  • Fragments plated by classes that can be acquired separately
  • Novel compounds featuring renowned Enamine Building Blocks

Distribution by covalent warheads

Examples of the molecules

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