Diverse covalent warheads with balanced reactivity
8 480 compounds
Covalent chemical probes have become essential for drug discovery in recent years. The impressive number of successful applications in protein drugability assessment, proteomics, and investigation of protein functions brought aspiration to the discovery of new covalent modifiers.
We are continuously working on elaborating parallel chemistry approaches and the synthesis of new covalent compounds of various classes. Enamine Covalent Collection comprises over 133k covalent binders and is frequently updated with new warhead types. The acquired experience and knowledge on stability and selectivity were applied to the design of our new Covalent Fragment Library.
The renewed library has been designed to represent Enamine’s most recent scaffolds in combination with the most interesting covalent anchors. Careful choice of the latest attractive and highly tractable covalent functionalities makes this library the most reliable source of covalent fragments.
All compounds passed rigorous QC before formatting to ensure the high quality of our library.
Covalent Fragment Library is available for fast supply in multiple formats, including the following most popular options.
Typical Formats
Catalog No.
Covalent Fragment Library
CFL-8480-40-Y-20
Compounds
8 480
27 plates
Amount
40 μL of 20 mM DMSO solutions
Plates and formats
384-well plates, Labcyte PP-0200; 320 compounds per plate; 1, 2 and 23,24 columns empty
Price
Catalog No.
Acrylamide Library
ACR-2240-20-Y-100
Compounds
2 240
7 plates
Amount
20 μL of 100 mM DMSO solutions
Plates and formats
384-well microplates, Greiner #781280; 320 compounds per plate; first two and last two columns empty
Price
Catalog No.
Cyanacrylamide Library
CACR-800-25-X-100
Compounds
800
10 plates
Amount
25 μL of 100 mM DMSO solutions
Plates and formats
96-well plates, Greiner #650201; 80 compounds per plate; 1 and 12 columns empty
Price
Catalog No.
Chloroacetamide Library
CLA-1360-50-X-100
Compounds
1 360
17 plates
Amount
50 μL of 100 mM DMSO solutions
Plates and formats
96-well plates, 2D-barcoded Matrix #4271; 80 compounds per plate; 1 and 12 columns empty
Price
Catalog No.
Butynamide Library
BTA-400-100-X-20
Compounds
400
5 plates
Amount
100 μL of 20 mM DMSO solutions
Plates and formats
96-well plates, Greiner #650201; 80 compounds per plate; 1 and 12 columns empty
Price
Catalog No.
Bicyclobutanes Library
BCB-320-40-Y-20
Compounds
320
1 plates
Amount
40 μL of 20 mM DMSO solutions
Plates and formats
384-well echo plates, Labcyte PP-0200; 320 compounds per plate; 1, 2 and 23, 24 columns empty
Price
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Covalent Fragment Library
Library code: CFL-8480
Version: 31 January 2025
8 480 compounds
Acrylamide Fragments
Library code: ACR-2240
Version: 10 May 2023
2 240 compounds
Chloroacetamide Fragments
Library code: CLA-1360
Version: 22 November 2023
1 360 compounds
Cyanacrylamide Fragments
Library code: CACR-800
Version: 3 July 2023
800 compounds
Butynamide Fragments
Library code: BTA-400
Version: 10 May 2023
400 compounds
Bicyclobutanes Library
Library code: BCB-320-40-X-20
Version: 9 August 2023
320 compounds
Sulfonyl Fluorides
Version: 30 July 2023
960 compounds
Disulfide Fragments
Library code: DSF-320
Version: 10 July 2023
320 compounds
Key features
- Careful choice of warheads: only experimentally confirmed reactivity, no over-reactive warheads, no alternative reactive functionalities.
- Stable in DMSO and suitable for multiple freeze-thaw cycles.
- Advanced covalent binders: balanced reactivity covalent binders, no promiscuous binders
- Fragments are pre-plated by classes and can be acquired separately.
- The latest compounds featuring renowned Enamine Building Blocks.
Composition of the Library by the type of covalent binders
Examples of compounds in the library
